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Information about Zyban.
In clinical trials with ZYBAN conducted in nondepressed smokers.the incidence of neuropsychiatric side effects was generally comparable to placebo. However.in the postmarketing experience.patients taking ZYBAN to quit smoking have reported similar types of neuropsychiatric symptoms to those reported by patients in the clinical trials of bupropion for depression.
In humans.following oral administration of Zyban.peak plasma concentration (C max ) of bupropion is usually achieved within 3 hours.
Treatment with ZYBAN should be continued for 7 to 12 weeks. If the patient has not quit smoking after 7 to 12 weeks.it is unlikely that he or she will quit during that attempt so treatment with ZYBAN should probably be discontinued and the treatment plan reassessed. The goalof therapy with ZYBAN is complete abstinence.
In addition to the adverse reactions noted above.the following adverse reactions have been reported in clinical trials with the sustained-release formulation of bupropion in depressed subjects and in nondepressed smokers.as well as in clinical trials with the immediate-release formulation of bupropion.
When you start taking Zyban you may continue to smoke for about 1 week after you start the medicine. Set a date to quit smoking during the second week of treatment. Talk to your doctor if you are having trouble quitting after you have used Zyban for at least 7 weeks.
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