Glitazones such as actos can be combined with these to create an enhancement of the blood sugar lowering effect.
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There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with ACTOS.
Dose related fluid accumulation (edema) can occur especially when combined with insulin. Fluid accumulation can worsen or lead to heart failure. Actos should not be used in patients with heart disease classified by the New York Heart Actos administrativos costa rica (NYHA) as Class III and IV heart failure or symptomatic heart failure.
Hypoglycemia Edema Pain in legs or arm Back Pain Chest Pain Cardiac Failure Headache Weight Gain Dizziness Flatulence Sinusitis Pharyngitis Myalgia (muscle aches) Bladder Cancer Macular Edema Bone Fractures Ovulation in anovulatory women.
Table 5. PROactive Trial. Incidence and Types of Adverse Events Reported in >5% of Patients Treated with ACTOS and More Commonly than Placebo.
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