This was an adequate and well-controlled, two-year study evaluating the efficacy of clozaril relative to olanzapine in reducing the risk of suicidal behavior in patients with schizophrenia or schizoaffective disorder.

Find out about Clozaril.

Clozapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are taking Clozaril.

Frequency not reported . Muscle pain.muscle spasms.muscle weakness.neck muscle spasm.systemic lupus erythematosus.

The Clozaril Patient Monitoring Service maintains a database which includes all patients who have developed abnormal leucocyte or neutrophil findings and who should not be re-exposed to Clozaril.

There have been no controlled human pregnancy studies on the effects of Clozaril. It is not known whether the drug can be transferred via human breast milk and harm a baby.but animal studies indicate the drug may be present in breast milk and potentially harm a nursing infant . Therefore.talk . to your doctor if you are pregnant.planning to become pregnant.or are nursing before you take Clorazil.

Pulmonary embolism and deep-vein thrombosis have occurred in patients treated with CLOZARIL. Consider the possibility of pulmonary embolism in patients who present with deep-vein thrombosis.acute dyspnea.chest pain.or with other respiratory signs and symptoms. Whether pulmonary embolus and deep vein thrombosis can be attributed to clozapine or some characteristic(s) of patients is not clear.

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the mechanism of clozaril-induced agranulocytosis is unknown; nonetheless, it is possible that causative factors may interact synergistically to increase the risk and or severity of bone marrow suppression.