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NSAIDs.including piroxicam.can cause serious gastrointestinal events including bleeding.ulceration.and perforation of thestomach.small intestine or large intestine.which can be fatal. These serious adverse events can occur at any time.with or without warning symptoms.in patients treated with NSAIDs.

Feldene dor nas costas of ALT or AST (less than three times ULN) may occur in up to 15% of patients treated with NSAIDs including piroxicam.

The following adverse reactions have been identified during post approval use of FELDENE. Because these reactions are reported voluntarily from a population of uncertain size.it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

This medicine may raise the chance of heart and blood vessel side effects like heart attack and stroke. If these happen.they can be deadly. The risk of these side effects may be greater if you have heart disease or risks for heart disease. However.the risk may also be raised in people who do not have heart disease or risks for heart disease. The risk feldene dor nas costas these health problems can happen as soon as the first weeks of using Feldene (piroxicam capsules) and may be greater with higher doses or with long-term use. Do not use Feldene (piroxicam capsules) right before or after bypass heart surgery. This medicine may raise the chance of very bad and sometimes deadly stomach or bowel side effects like ulcers or bleeding. The risk is greater in older people. The risk is also greater in people who have had stomach or bowel ulcers or bleeding before. These problems may occur without warning signs. Talk with the doctor.

Safety during pregnancy has not been established. Use in late pregnancy may cause premature closing of the ductus arteriosus in the fetus.

Undesirable effects may be minimised by using the minimum effective dose for the shortest duration necessary to control symptoms. The benefit and tolerability of treatment should be reviewed within 14 days. If continued treatmentis considered necessary.this should be accompanied by frequent review.

NSAIDs.including piroxicam.can cause serious skin adverse reactions such as exfoliative dermatitis.Stevens-Johnson Syndrome (SJS).and toxic epidermal necrolysis (TEN).which can be fatal. These serious events may occur without warning. Inform patients about the signs and symptoms of serious skin reactions.and to discontinue the use of FELDENE at the first appearance of skin rash or any other sign of hypersensitivity. FELDENE is contraindicated in patients with previous serious skin reactions to NSAIDs [see Contraindications (4)] .

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