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Alopecia occurs commonly in patients treated with cyclophosphamide. The hair can be expected to grow back after treatment with the drug or even during continued drug treatment.though it may be different in texture or color. Skin rash occurs occasionally in patients receiving the drug. Pigmentation of the skin and changes in nails can occur. Very rare reportsof Stevens-Johnson syndrome and toxic epidermal necrolysis have been received during postmarketing surveillance. due to the nature of spontaneous adverse event reporting.a definitive causal relationship to cyclophosphamide has not been established.
Interstitial pneumonitis has been reported as part of the postmarketing experience. Interstitial pulmonary fibrosis has been reported in patients receiving high doses of cyclophosphamide over a prolonged period.
May be administered IM.intraperitoneally.intrapleurally.by IV piggy-back.or by continuous IV infusion.
But I have been cytoxan infusion orders to my docs and they have to prepare me for the worst so they have told me that chemo would be necessary again if this is a return of the same kind of tumor Cytoxan infusion orders had the first time because it is very aggressive. Iam also ER/PR neg cytoxan infusion orders makes the cancer a little harder to control because we “negative girls” don’t have any aftercare meds like Tamox or Arimidex.
Allopurinol (Zyloprim) enhances the ability of cyclophosphamide to reduce . production of blood cells from the bone marrow.
nausea or vomiting (may be severe).loss of appetite.stomach pain or upset.diarrhea.temporary hair loss.a wound that will not heal.missed menstrual periods.changes in skin color (darkening).or changes in nails.
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