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Results of in vitro studies showed a weak antagonism of nevirapine by adefovirsee section 5.1this has not been confirmed in clinical trials and reduced efficacy is not expectedAdefovir did not influence any of thecommon CYP isoforms known to be involved in human drug metabolism and is excreted renallyNo clinically relevant drug-drug interaction is expected.
Limited human data are insufficient to determinerisk of infertility in humansbased on results from animal fertility studies conducted in ratstherapy may reduce fertility in females of reproductive potentialnot known if these effects on fertility are reversible.
It is not recommended to co-administer ketoconazole and Viramunesee section 4.4
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table global viramune sales k mt of key players suppliers 2012-2017 .
