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Patients should take Renagel with meals and adhere to their prescribed dietsThe tablets must be swallowed wholeDo not crushchew or break into pieces prior to administration.

Acid or sour stomach belching bloating constipation diarrhea excess air or gas in the stomach or intestines full feeling passing gas stomach discomfort or upset.

There are no data from the effect of sevelamer on fertility in humansStudies in animals have shown that sevelamer did not impair fertility in male or female rats at exposures at a human equivalent dose 2 times the maximum clinical trial dose of 13 g/daybased on a comparison of relative body surface area.

During post marketing experiencevery rare cases of increased thyroid stimulating hormoneTSHlevels have been reported in patients co-administered sevelamer hydrochloride and levothyroxineCloser monitoring of TSH levels is therefore recommended in patients receiving both medicinal products.

Closer monitoring of patients with hypothyroidism co-administered with sevelamer hydrochloride and levothyroxine is recommendedsee section 4.5

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in patients with secondary hyperparathyroidism renagel should be used within the context of a multiple therapeutic approach, which could include calcium supplements, 1,25-dihydroxy vitamin d 3 or one of its analogues to lower the intact parathyroid hormone ipth levels.

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