A potentially fatal symptom complex sometimes referred to as neuroleptic malignant syndrome nms has been reported in association with promethazine hcl alone or in combination with antipsychotic drugs.

Information about Promethazine.

Promethazine may cause other side effectsCall your doctor if you experience any unusual problems while you are taking this medication.

PROMETHAZINE HYDROCHLORIDE TABLETS USP SHOULD NOT BE USED IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION.

Get emergency medical help if you have any signs of an allergic reactionhivesdifficult breathingswelling of your facelipstongueor throat.

Treatment of overdosage is essentially symptomatic and supportiveOnly in cases of extreme overdosage or individual sensitivity do vital signsincluding respirationpulseblood pressuretemperatureand EKGneed to be monitoredActivated charcoal orally or by lavage may be givenor sodium or magnesium sulfate orally as a catharticAttention should be given to the reestablishment of adequate respiratory exchange through provision of a patent airway and institution of assisted or controlled ventilationDiazepam may be used to control convulsionsAcidosis and electrolyte losses should be correctedNote that any depressant effects of promethazine HClpromethazine hydrochlorideare not reversed by naloxoneAvoid analeptics which may cause convulsionsThe treatment of choice for resulting hypotension is administration of intravenous fluidsaccompanied by repositioning if indicatedIn the event that vasopressors are considered for the management of severe hypotension which does not respond to intravenous fluids and repositioningthe administration of norepinephrine or phenylephrine should be consideredEPINEPHRINE SHOULD NOT BE USEDsince its use in patients with partial adrenergic blockade may further lower the blood pressureExtrapyramidal reactions may be treated with anticholinergic antiparkinsonian agentsdiphenhydramineor barbituratesOxygen may also be administered.

Antiemetics should not be used in vomiting of unknown etiology in children and adolescentssee WARNINGS-Use in Pediatric Patients

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do not use if you are allergic to prochlorperazine or other phenothiazines such as chlorpromazine thorazine , fluphenazine permitil , perphenazine trilafon , promethazine adgan, pentazine, phenergan , thioridazine mellaril , or trifluoperazine stelazine .