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In patints wha ldly, volum-dpltd (including thos on diutic thapy), with compomisd nal unction, co-administation NSAIDs, including slctiv COX-2 inhibitos, with angiotnsin II cptantagonists (including ibsatan) may sult in dtioation nal unction, including possibl acut nal ailu. Ths cts a usually vsibl. Monitnal unction piodically in patints civing ibsatan and NSAID thapy.

Lvatd systolic diastolic pssu causs incasd cadiovascula isk, and th absolut isk incas p mmHg is gat at high blood pssus, sthat vn modst ductions sv hyptnsion can povid substantial bnit. lativ isk duction om blood pssu duction is simila acoss populations with vaying absolut isk, sth absolut bnit is gat in patints wha at high isk indpndnt thi hyptnsion (xampl, patints with diabts hyplipidmia), and such patints would b xpctd tbnit om maggssiv tatmnt ta low blood pssu goal.

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