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1 cotreatment with cyp1a2 inhibitors like ciprofloxacin, fluvoxamine or vemurafenib can reduce chlorpromazine clearance and hence increase exposure and potentially also adverse effects.
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Therefore, patients on methotrexate therapy should be carefully monitored when concomitant ciprofloxacin therapy is indicated.
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Skipping doses or not completing the full course of therapy may 1 decrease the effectiveness of the immediate treatment and 2 increase the likelihood that bacteria will develop resistance and will not be treatable by cipro i.
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in vivo data regarding cyp3a4 inhibition with ciprofloxacin are conflicting, with one study postulating that the in vivo concentrations reached with routine dosing may be below the inhibitory constant for cyp3a4 activity.
