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Call your doctor immediately if you experience any of the following serious side effectsFeversore throatand headache with a severe blisteringpeeling and red skin rash Any sign of skin rashno matter how mild Nauseaupper stomach painitchingloss of appetiteweight lossdark urineclay-colored stoolsjaundice Pain or bleeding when urinating Urinating less frequently or not at all Joint pain or flu symptoms Easy bruisingunusual bleedingor purple or red pinpoint spots under the skin Severe tinglingnumbnesspainor muscle weakness.

Some less serious side effects of allopurinol may includeVomiting Diarrhea Drowsiness Headache Muscle pain Changes in sense or taste.

Some patients with pre-existing renal disease or poor urate clearance have shown a rise in BUN during administration of ZyloprimAlthough the mechanism responsible for this has not been establishedpatients with impaired renal function should be carefully observed during the early stages of administration of Zyloprim and the dosage decreased or the drug withdrawn if increased abnormalities in renal function appear and persist.

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diuretics may increase the amount of zyloprim in the blood.