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In studies and lawsuits filed by mothers and families of injured babiesa number of birth defects are linked to the medicationTheseinclude:

Get emergency medical help if you have any of these signs of an allergic reactionhivesdifficulty breathingswelling of your facelipstongueor throat.

The FDA had previously noted that ondansetron could increase the risk of developing QT interval prolongationThe agency also pointed to articles published in the medical literature that describe QT interval prolongation with ondansetron.

The development of serotonin syndrome has been reported with 5-HT 3 receptor antagonists aloneMost reports have been associated with concomitant use of serotonergic drugse.gselective serotonin reuptake inhibitorsSSRIsserotonin and norepinephrine reuptake inhibitorsSNRIsmonoamine oxidase inhibitorsmirtazapinefentanyllithiumtramadoland intravenous methylene blueSome of the reported cases were fatalSerotonin syndrome occurring with overdose of ZOFRAN alone has also been reportedThe majority of reports of serotonin syndrome related to 5-HT 3 receptor antagonist use occurredin a post-anesthesia care unit or an infusion center.

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