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Ascorbic AcidUSPAbbottBenztropine MesylateUSPMS&DCytarabineUSPUpjohnDexamethasone Sodium PhosphateUSPESIMS&DDiphenhydramine HydrochlorideUSPParke-DavisDoxorubicin HydrochlorideUSPAdriaHeparin SodiumUSPESIHydrocortisone Sodium PhosphateMS&DLidocaine HydrochlorideUSPESIMulti-Vitamin Infusionmust be refrigerated-USVVitamin B Complex with Ascorbic AcidRoche

Metoclopramide increases the tone and amplitude of gastricespecially antralcontractionsrelaxes the pyloric sphincter and the duodenal bulband increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transitIt increases the resting tone of the lower esophageal sphincterIt has littleif anyeffect on the motility of the colon or gallbladder.

Renal impairment affects the clearance of metoclopramideIn a study with patients with varying degrees of renal impairmenta reduction in creatinine clearance was correlated with a reduction in plasma clearancerenal clearancenon-renal clearanceand increase in elimination half-lifeThe kinetics of metoclopramide in the presence of renal impairment remained linear howeverThe reduction in clearance as a result of renal impairment suggests that adjustment downward of maintenance dosage should be done to avoid drug accumulation.

Reglan Injectionmetoclopramide injectionUSPis compatible for mixing and injection with the following dosage forms to the extent indicated below:

Metoclopramide should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactionssince the frequency and severity of seizures or extrapyramidal reactions may be increased.

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