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Methotrexate is generally a safe medication that is tolerated by most patients who take the low dosages prescribed by rheumatologists to treat arthritis.

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Nausea or vomiting stomach pain or upset diarrhea hair loss tiredness dizziness chills headache sores in your lungs mouth sores painful skin sores bronchitis fever bruising more easily increased risk of infection sun sensitivity rash stuffy or runny nose and sore throat abnormal results on liver function testsmay indicate liver damagelow blood cell levels.

If you are a manuse a condom to keep from causing a pregnancy while you are using methotrexateContinue using condoms for at least 3 months after your last dose.

12 mg/m2 intrathecally every 2 to 5 days until the cell count of the CSF returns to normalAt this pointone additional dose is advisableAdministration at intervals of less than 1 week may result in increased subacute toxicity.

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however, dosing of methotrexate in this study was low.

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