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Severe hypersensitivity reactionsincluding anaphylactic reactions and severe cutaneous adverse reactionsSCARsuch as Stevens-Johnson syndromeSJStoxic epidermal necrolysisTENacute generalized exanthematous pustulosisAGEPand erythema multiformeEMhave been reported in patients receiving Lincocin therapyIf an anaphylactic reaction or severe skin reaction occursLincocin should be discontinued and appropriate therapy should be initiatedsee ADVERSE REACTIONS
Lincomycin was not found to be mutagenic in the Ames Salmonella reversion assay or the V79 Chinese hamster lung cells at the HGPRT locusIt did not induce DNA strand breaks in V79 Chinese hamster lung cells as measured by alkaline elution or chromosomal abnormalities in cultured human lymphocytesIn vivolincomycin was negative in both the rat and mouse micronucleus assays and it did not induce sex-linked recessive lethal mutations in the offspring of male DrosophilaHoweverlincomycin did cause unscheduled DNA syntheses in freshly isolated rat hepatocytes.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of LINCOCIN and other antibacterial drugsLINCOCIN should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.
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