Diuretics such as furosemide lasix and bumetanide bumex may have no affect on lithium concentrations in blood.
Information about Lasix.
Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolismparticularly in elderly patientsAs with any effective diureticelectrolyte depletion may occur during LASIX therapyespecially in patients receiving higher doses and a restricted salt intakeHypokalemia may develop with LASIXespecially with brisk diuresisinadequate oral electrolyte intakewhen cirrhosis is presentor during concomitant use of corticosteroidsACTHlicorice in large amountsor prolonged use of laxativesDigitalis therapy may exaggerate metabolic effects of hypokalemiaespecially myocardial effects.
Furosemide can pass into breast milk and may harm a nursing babyThis medicine may also slow breast milk productionTell your doctor if you are breast-feeding a baby.
Furosemide was devoid of mutagenic activity in various strains of Salmonella typhimurium when tested in the presence or absence of an in vitro metabolic activation systemand questionably positive for gene mutation in mouse lymphoma cells in the presence of rat liver S9 at the highest dose testedFurosemide did not induce sister chromatid exchange in human cells in vitrobut other studies on chromosomal aberrations in human cells in vitro gave conflicting resultsIn Chinese hamster cells it induced chromosomal damage but was questionably positive for sister chromatid exchangeStudies on the induction by furosemide of chromosomal aberrations in mice were inconclusiveThe urine of rats treated with this drug did not induce gene conversion in Saccharomyces cerevisiae
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furosemide marketed under the brand name lasix.
