Because of the potential for serious adverse reactions in breastfed infants from femara, advise lactating women not to breastfeed while taking femara and for at least 3 weeks after the last dose.

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NoteBreast Cancer News is strictly a news and information website about the diseaseIt does not provide medical advicediagnosis or treatmentThis content is not intended to be a substitute for professional medical advicediagnosisor treatmentAlways seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical conditionNever disregard professional medical advice or delay in seeking it because of something you have read on this website.

To determine the efficacy of Letrozole plus Imatinib Mesylate in patients with ER and or PgR positive metastatic breast cancerEfficacy will be measured by the rate of clinical tumor responseTo determine the safety and tolerability of Letrozole plus Imatinib Mesylate in patients with metastatic breast cancerTo determine the time to disease progression and overall survival in patients with metastatic breast cancer who are treated with Letrozole plus Imatinib Mesylate.

You may be advised to take calcium and vitamin D supplements to help prevent bone lossWeight bearing exercise and a healthy diet rich in calcium and vitamin D can also help protect your bone healthYour doctor will check your bone health before starting therapyThis is done with a bone density scanDEXA scanWomen with no weakening of bones prior to aromatase inhibitor therapy will have a follow-up scan around one year after starting therapyand then every one to two yearsIf the scan shows that you already have some bone weakeningyour doctor may order a type of medication called a bisphosphonateThese therapies have been shown to protect the bones from bone loss in women taking aromatase inhibitorsIf the bone density remains stablescans can then be done every two years.

Letrozole is a drug used as hormone therapy for the treatment of breast cancerand included in a group of drugs called aromatase inhibitors due to its mechanism of actionEstrogen and progesterone are female sex hormones that promote cancer growthWhile in menstruating womenthese hormones are produced in the ovariesin menopausal womenit is produced in the fat tissue through a process known as aromataseThereforeletrozole interferes with this process in order to decrease the levels of estrogen in the body andconsequentlystop or slow down cancer growthor decrease the probability of cancer recurrence after surgeryLetrozole is only effective in hormone sensitive or hormone receptor positive breast cancer and its use is limited to women after menopause.

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